![[China] Human Type III Collagen and Human Growth Factors (GF) Gain Attention as Innovative Cosmetic Ingredients](https://res.cloudinary.com/dte6zhuck/image/upload/v1780367173/blogContent/art_17803021476046_75e692.jpg)
Human Type III Collagen and Human Growth Factors (GF) Gain Attention as Innovative Cosmetic Ingredients
The nation’s only 12th Functional Cosmetics R&D Innovation Forum successfully held
The cosmetics market paradigm is rapidly shifting beyond simple skin surface care toward biotechnology that awakens the recovery power of skin cells themselves. At the recently held functional cosmetics forum, the latest research results on human Type III collagen and human growth factors, considered next-generation core ingredients, were unveiled and drew strong industry attention.
A Skin Regeneration Paradigm Centered on Cellular Recovery
Research focused on cellular recovery to overcome the rebound effect
The skin rebound effect, in which loss of elasticity and dryness repeatedly occur despite ongoing skin care, has long been a key challenge for the industry. Researchers identified the cause of this issue not on the skin surface, but in the reduced recovery capacity of the cells themselves. The key to skin health lies not simply in adding nutrients, but in encouraging cells to function again on their own. As a result, demand for fillers is clearly shifting toward biomaterials that regenerate the skin itself.
The original technology of the genetically recombinant ingredient HUGRO
HUGRO, developed through genetically recombinant technology, has a unique structure that acts directly on skin cells and activates intercellular signal transmission. It incorporates AUT technology, which suppresses protein degradation to maximize the lasting efficacy of active ingredients, and BMTS technology, which delivers active ingredients deep into the dermal layer of the skin. This combination of advanced biotechnology creates a clear point of differentiation from existing functional ingredients.
According to Team Leader Kim Myungseon of the Bio Research Institute, this ingredient presents new possibilities beyond a simple cosmetic component.
“HUGRO is being evaluated as an ingredient based on the concept of a cellular healing agent beyond a simple raw material, and it presents an approach different from existing skin boosters or functional ingredients”
Research aimed at fundamental healing at the cellular level is expected to become a new standard in the next-generation cosmetics market.
Reverse Aging Technology Based on High-Purity Recombinant Collagen and Human Growth Factors
The stability and skin tissue regeneration efficacy of high-purity recombinant collagen
Recombinant Type III collagen and elastin produced through an E. coli system are highly safe compared with conventional animal-derived ingredients. Their greatest strengths are high biocompatibility, low immune response, and no risk of viral infection. In addition, strict quality control maintains a high purity of over 95%, ensures batch-to-batch consistency, and enables large-scale mass production. During development, the focus was on reducing immune response and producing a natural triple helix structure without impurities at high purity.
Unlike collagen I, which is responsible for the tensile strength of the skin, collagen III plays a key role in skin repair by promoting cell proliferation and fibroblast activity. Through experiments, researchers directly confirmed that both elastin BMTS and collagen BMTS ingredients fully penetrate to the dermal layer of the skin. After completing verification of dermal penetration efficacy, GMP review is currently underway, and commercialization is approaching not only for topical forms but also for directly injectable collagen.
The signaling mechanism of human growth factors that promote skin regeneration
Human growth factors (GF) are signaling proteins that are naturally produced in the body and bind to specific receptors on the cell surface. They strongly promote cell proliferation and collagen synthesis, delivering outstanding efficacy in wound healing and tissue regeneration. As the ability to replenish cells declines with age, restoring it through growth factor supplementation has made these ingredients highly notable as next-generation reverse-aging components. CEO Oh Dal-kyun shared the results of parabiosis experiments showing that the biological capacity of aged subjects was restored through growth factors in the blood, emphasizing the value of the ingredient.
CEO Oh Dal-kyun explains that the penetration limitations of growth factors actually prove their value as powerful active cosmetic ingredients.
“As we age, the ability of cells to exchange and replenish decreases every year, but supplementing the skin with growth factors can restore skin regeneration capacity and suppress aging. In other words, if we can raise growth factor levels even slightly, reverse aging becomes possible”
This principle is functioning as a key to overcoming the technical limitations of cosmetic ingredients.
Maximizing the stability of growth factors through liposome technology
Protein growth factors have faced limitations because they easily denature in heat and liquid environments and have difficulty penetrating the skin. To overcome this, patented liposomal encapsulation technology was applied, enabling efficacy to be maintained stably for more than two years at room temperature. Through this innovative approach, safety and room-temperature storage stability were secured, while production costs were also reduced. Clinical trial results proved excellent wrinkle improvement and hair growth promotion effects in the test group that applied a cream containing this ingredient every day. Furthermore, it highlighted the importance of selecting the most suitable bioactive growth factors for cosmetics and created a significant impact.
Closing
The rapid advancement of biotechnology is elevating the role of cosmetics from simple skin protection to restoring the skin’s inherent regenerative capacity at the cellular level. The development of innovative ingredients using human-like collagen and growth factors will lead the opening of the reverse-aging beauty market, which fundamentally slows skin aging. In the future, high-performance biocosmetics that have undergone thorough technical verification and convergence are expected to become mainstream in the global market.
In the rapidly changing cosmetics market, developing high-performance cosmetics that incorporate innovative biotechnology like this is a key to sustainable brand growth. Based on excellent formulation technology and reliable partnerships, we will be a dependable guide in developing high-quality products that lead the market.
